Hepatox


Hepatox® is a bibliographical tool used as a support for:

  • evaluating the role of drug(s) as a cause of liver injury,

  • safety, by avoiding to prescribe any drug known to cause any type of liver injury in a patient at risk,

  • pharmacoepidemiological studies especially for case/no-case type.

    This specific type of database requires anyway a few safety practices. Actually, three precautions have to be taken by the readers prior using our database:
    1. a drug which is known for its hepatotoxicity is not always the only cause of a liver injury observed in a patient;

    2. and vice versa, the liver injury may come from another drug which is not registered in our list;

    3. the hepatotoxic potential of each drug could be evaluated through the number of references in the index. Nevertheless, this method is strongly inadvisable for drugs marketed in only one country.

    Liver disorders are classified in accordance with the following definitions:

  • biological disorders are defined as an asymptomatic rise in AST and ALT ranged from 1,1 to 6 times the upper limit of the normal (xULN), and/or rise in alkaline phosphatases ranged from 1,1 to 1,7 xULN;
  • acute disorders are defined either as a rise in AST and ALT of more than 6 xULN, and/or rise in alkaline phosphatases of more than 1,7 xULN. The type of pattern of the liver injury was related to the histological examination of the liver, or as a default, through the ratio (R) of the maximum xULN expression rises in aminotransferases and in alkaline phosphatases (R<2: cholestatic; R>5: cytolytic; R ranged from 2 to 5: mixed).
  • severe disorders are defined as fulminant or subfulminant hepatitis or death or liver injury accompanied by signs of liver failure (encephalopathy, PT<60% or Factor V<60%).
  • chronic disorders are defined as a persistent rise in liver enzymes during a period of more than six months or as a chronic hepatitis as defined by histology.
  • the other hepatic disorders are classified in accordance with the histological definitions. List of the terms used in the 'Particularities' section:

    specific antibodies:

  • anti-M: anti-Mitochondria
  • anti-LM: anti-Liver Microsome
  • anti-LKM: anti-Liver and Kidney Microsome
  • anti-SM: anti-Smooth Muscle
  • anti-N: anti-Nuclear

    miscellaneous:

  • CR/.: Cross-Reaction with
  • FNH: Focal Nodular Hyperplasia
  • RNH: Regenerative Nodular Hyper
  • I/.: Potentiation in case of combination with
  • HAI: related to Hepatic Artery Infusion
  • HCC: Hepatocellular Carcinoma
  • IMLS: Infectious Mononucleosis Like-Syndrome
  • OLT : Orthoptic Liver Transplantation
  • PBC: Primary Biliary Cirrhosis
  • VOD: Veno-Occlusive-Disease
  • NA: Not Available

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