Pancreatox


Pancreatox® is a bibliographical tool used as a support for:

  • evaluating the role of drug(s) as a cause of pancreatic disorder,

  • safety, by avoiding to prescribe any drug known to cause any type of pancreatic disorder in a patient at risk,

  • pharmacoepidemiological studies especially for case/no-case type.

    This specific type of database requires anyway a few safety practices. Actually, three precautions have to be taken by the readers prior using our database:
    1. a drug which is known for its pancreatotoxicity is not always the only cause of a pancreas disorder observed in a patient;

    2. and vice versa, the pancreas disorder may come from another drug which is not registered in our list;

    3. the pancreatotoxic potential of each drug could be evaluated through the number of references in the index. Nevertheless, this method is strongly inadvisable for drugs marketed in only one country.

    References as well as cases reports are available in the database.

    Pancreatic disorders are classified in accordance with the following definitions.

    In 1985, when the file was created, we have kept the following definitions:

  • 'biological pancreatitis', it represents a rise in serum pancreatic enzymes (i.e. amyalsemia and/or lipasemia) of less than 3 times the upper limit of the normal (xULN); or a rise in the serum pancreatic enzymes <2 xULN in combination with abdominal pain. Concerning these two possibilities, the pancreas imaging (laparotomy included) has not shown any abnormality or has not been performed.

  • 'acute pancreatitis', the disorder was confirmed by pancreas imaging (laparotomy included); or it represents a rise in the serum pancreatic enzymes (i.e. amylasemia and/or lipasemia) but of more than or equal to 3 xULN; or a rise in the serum pancreatic enzymes (i.e. amylasemia and/or lipasemia) of more than or equal to 2 xULN in combination with relevant abdominal pain.

  • 'chronic pancreatitis', the disorder was confirmed by pancreas imaging (laparotomy included); or by a persistent rise in the serum pancreatic enzymes (i.e. amylasemia and/or lipasemia).

  • Buy on App Store Buy on Google Play